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Prozac. Paxil. Zoloft.
Turn on your television and you are likely to see a commercial for one of the
many selective serotonin reuptake inhibitors (SSRIs) on the market. We hear a
lot about them, but do we really understand how these drugs work and what risks
are involved for anyone who uses them?
Let Them Eat
Prozac explores the history of SSRIs—from their early development to their
latest marketing campaigns—and the controversies that surround them. Initially,
they seemed like wonder drugs for those with mild to moderate
depression—patients take just one daily dose, and unlike the tranquilizers that
were popular in the 1960s, they supposedly did not lead to addiction. When
Prozac was released in the late 1980s, David Healy was among the psychiatrists
who prescribed it. But he soon observed that some of these patients became
agitated and even attempted suicide. Studies were soon published, citing
numerous cases in which patients became anxious and reported increased suicidal
thoughts while taking Prozac. Could the new wonder drug actually be making
patients worse?
Healy draws on his own
research and expertise to demonstrate the potential hazards associated with
these drugs. He intersperses case histories with insider accounts of the
research leading to the development and approval of SSRIs as a treatment for
depression. Let Them Eat Prozac clearly demonstrates that the problems
go much deeper than a disturbing side-effect of a particular drug. Current FDA
regulations encourage drug companies to patent a specific compound and market it
effectively to a large population on the basis of minimal effectiveness in a
handful of trials.
The pharmaceutical
industry would like us to believe that SSRIs can safely treat depression,
anxiety, and a host of other mental problems. But as Let Them Eat
Prozac reveals, this "cure" may be worse than the
disease.
David
Healy
is a former secretary of the British Association for Psychopharmacology and
author of over 120 articles and 12 books, including The Antidepressant
Era and The Creation of
Psychopharmacology.
Recent Food & Drug Administration hearings have explored links between antidepressant use and suicide. Expert testimony on the safety of these drugs conflicts, and pharmaceutical companies have been accused of covering up evidence of serious side effects. In his timely new book, psychiatrist Healy (Univ. of Wales Coll. of Medicine, U.K.; The Antidepressant Era) chronicles these very issues at length, drawing on his extensive experience in antidepressant studies and involvement in legal actions against drug manufacturers. (He was fired from a position at the University of Toronto for his outspokenness.) In effect, Healy is continuing the conversation started by Peter D. Kramer (Listening to Prozac) and Peter Breggin (Talking Back to Prozac; The Anti-Depressant Fact Book), both of whom are psychiatrists concerned with the way antidepressants are being marketed and what the current love affair with mood-altering drugs means in our culture. Healy has the advantage of access to internal pharmaceutical industry documents and makes a strong case. Somewhat academic in tone, his book includes extensive notes to relevant case law as well as medical literature. Recommended for larger public libraries and special collections in public policy, medicine, and public health.-Eris Weaver, Redwood Health Lib., Petaluma, CA Copyright 2004 Reed Business Information.
More Reviews and RecommendationsDavid Healy is professor of psychiatry at Cardiff University and a former secretary of the British Association for Psychopharmacology. He is the author of over 120 articles and 12 books, including The Antidepressant Era and The Creation of Psychopharmacology.