Kohl (Cardio Mechano-Electric Feedback Lab, Oxford University) documents the role of mechano-electric feedback (MEF) in electrical and mechanical pathological remodeling of cardiac function. Sections cover sub-cellular mechanisms of cardiac MEF, effects of MEF on cardiac cellular electrophysiology, experimental manifestations of MEF in the heart, cardiac MEF in normal physiology, cardiac MEF as a pathogenic mechanism, MEF as a mechanism involved in therapeutic interventions, and the outlook for the future. B&w and color photos and medical images are included. Annotation ©2005 Book News, Inc., Portland, OR
Reviewer:Hamid Afshar, MD (Ochsner Clinic Foundation)
Description:This book is written by recognized experts in the field of cardiovascular physiology, cardiac electrophysiology, and cardiac biology.
Purpose:The heart is a mechano-sensitive organ. Stretching of cardiac tissue affects a wide range of electrical, structural, and functional properties. The so-called mechano-electric feedback (MEF) is believed in many cases to be mediated by stretch-activated ion channels (SAC) . This book focuses on mechanically induced changes that directly or indirectly affect heart rate and rhythm and represents an important step in documenting a significant role of MEF.
Audience:The targeted audience for this book includes cardiovascular physiologists, biologists, and cardiac electrophysiologists.
Features:The book is divided into seven sections, which in a systematic approach, highlights the core concepts of cardiac MEF in the initial sections of the book. Subsequent sections continue to explore the acute and chronic influences of MEF in normal physiology and pathologic conditions, and finally focus on MEF as a mechanism involved in therapeutic interventions.
Assessment:The editors succeed in providing a comprehensive review of a broad scope and less established idea of MEF whose role in normal and pathological conditions has become an exciting new chapter in contemporary biology. The book is very well written and is an excellent addition to the library of investigators in this field.