| Ch. 1 | Initial approach to the patient : history and physical examination | 3 |
| Ch. 2 | Examination of the blood | 11 |
| Ch. 3 | Examination of the marrow | 21 |
| Ch. 4 | Structure of the marrow and the hematopoietic microenvironment | 35 |
| Ch. 5 | The lymphoid tissues | 73 |
| Ch. 6 | Hematology of the newborn | 81 |
| Ch. 7 | Hematology during pregnancy | 101 |
| Ch. 8 | Hematology in older persons | 111 |
| Ch. 9 | Genetic principles and molecular biology | 125 |
| Ch. 10 | Cytogenetics and gene rearrangement | 137 |
| Ch. 11 | Apoptosis | 151 |
| Ch. 12 | Cell cycle regulation and hematological disorders | 159 |
| Ch. 13 | Signal transduction pathways | 173 |
| Ch. 14 | The cluster of differentiation (CD) antigens | 183 |
| Ch. 15 | Hematopoietic stem cells, progenitors, and cytokines | 201 |
| Ch. 16 | The inflammatory response | 221 |
| Ch. 17 | Innate immunity | 231 |
| Ch. 18 | Dendritic cells and the control of innate and adaptive immunity | 239 |
| Ch. 19 | Pharmacology and toxicity of antineoplastic drugs | 249 |
| Ch. 20 | Treatment of infections in the immunocompromised host | 275 |
| Ch. 21 | Principles of antithrombotic therapy | 283 |
| Ch. 22 | Principles of hematopoietic cell transplantation | 301 |
| Ch. 23 | Principles of immune cell therapy | 323 |
| Ch. 24 | Principles of vaccine therapy | 333 |
| Ch. 25 | Principles of therapeutic apheresis : indications, efficacy, complications | 337 |
| Ch. 26 | Principles of gene transfer for therapy | 345 |
| Ch. 27 | Pain management | 355 |
| Ch. 28 | Morphology of the erythron | 369 |
| Ch. 29 | Composition of the erythrocyte | 387 |
| Ch. 30 | Production of erythrocytes | 393 |
| Ch. 31 | Destruction of erythrocytes | 405 |
| Ch. 32 | Clinical manifestations and classification of erythrocyte disorders | 411 |
| Ch. 33 | Aplastic anemia | 419 |
| Ch. 34 | Pure red cell aplasia | 437 |
| Ch. 35 | Anemia of chronic renal failure | 449 |
| Ch. 36 | Anemia of endocrine disorders | 459 |
| Ch. 37 | The congenital dyserythropoietic anemias | 463 |
| Ch. 38 | Paroxysmal nocturnal hemoglobinuria | 469 |
| Ch. 39 | Folate, cobalamin, and megaloblastic anemias | 477 |
| Ch. 40 | Disorders of iron metabolism | 511 |
| Ch. 41 | Anemia resulting from other nutritional deficiencies | 555 |
| Ch. 42 | Anemia associated with marrow infiltration | 561 |
| Ch. 43 | Anemia of chronic disease | 565 |
| Ch. 44 | Disorders of the red blood cell membrane : hereditary spherocytosis, elliptocytosis, and related disorders | 571 |
| Ch. 45 | Disorders of red cells resulting from enzyme abnormalities | 603 |
| Ch. 46 | Disorders of globin synthesis : the thalassemias | 633 |
| Ch. 47 | Disorders of hemoglobin structure : sickle cell anemia and related abnormalities | 667 |
| Ch. 48 | Methemoglobinemia and other causes of cyanosis | 701 |
| Ch. 49 | Hemolytic anemia resulting from physical injury to red cells | 709 |
| Ch. 50 | Hemolytic anemia resulting from chemical and physical agents | 717 |
| Ch. 51 | Hemolytic anemia resulting from infections with microorganisms | 723 |
| Ch. 52 | Hemolytic anemia resulting from immune injury | 729 |
| Ch. 53 | Alloimmune hemolytic disease of the newborn | 751 |
| Ch. 54 | Acute blood loss anemia | 767 |
| Ch. 55 | Hypersplenism and hyposplenism | 773 |
| Ch. 56 | Primary and secondary polycythemias (erythrocytosis) | 779 |
| Ch. 57 | The hematologic aspects of porphyria | 803 |
| Ch. 58 | Hereditary and acquired sideroblastic anemias | 823 |
| Ch. 59 | Morphology of neutrophils, eosinophils, and basophils | 831 |
| Ch. 60 | Composition of neutrophils | 847 |
| Ch. 61 | Production, distribution, and fate of neutrophils | 855 |
| Ch. 62 | Eosinophils and their disorders | 863 |
| Ch. 63 | Basophils and mast cells and their disorders | 879 |
| Ch. 64 | Classification and clinical manifestations of neutrophil disorders | 899 |
| Ch. 65 | Neutropenia and neutrophilia | 907 |
| Ch. 66 | Disorders of neutrophil function | 921 |
| Ch. 67 | Morphology of monocytes and macrophages | 961 |
| Ch. 68 | Biochemistry and function of monocytes and macrophages | 971 |
| Ch. 69 | Production, distribution, and fate of monocytes and macrophages | 979 |
| Ch. 70 | Classification and clinical manifestations of disorders of monocytes and macrophages | 983 |
| Ch. 71 | Monocytosis and monocytopenia | 987 |
| Ch. 72 | Inflammatory and malignant histiocytosis | 993 |
| Ch. 73 | Lipid storage diseases | 1009 |
| Ch. 74 | Morphology of lymphocytes and plasma cells | 1023 |
| Ch. 75 | Composition and biochemistry of lymphocytes and plasma cells | 1031 |
| Ch. 76 | Lymphopoiesis | 1039 |
| Ch. 77 | Functions of B lymphocytes and plasma cells in immunoglobulin production | 1051 |
| Ch. 78 | Functions of T lymphocytes : T cell receptors for antigen | 1065 |
| Ch. 79 | Functions of natural killer cells | 1077 |
| Ch. 80 | Classification and clinical manifestations of lymphocyte and plasma cell disorders | 1083 |
| Ch. 81 | Lymphocytosis and lymphocytopenia | 1087 |
| Ch. 82 | Immunodeficiency diseases | 1099 |
| Ch. 83 | Hematological aspects of human immunodeficiency syndrome | 1109 |
| Ch. 84 | Mononucleosis syndromes | 1135 |
| Ch. 85 | Classification and clinical manifestations of the clonal myeloid disorders | 1147 |
| Ch. 86 | Myelodysplastic syndromes (clonal cytopenias and oligoblastic leukemia) | 1157 |
| Ch. 87 | Acute myelogenous leukemia | 1183 |
| Ch. 88 | Chronic myelogenous leukemia and related disorders | 1237 |
| Ch. 89 | Idiopathic myelofibrosis (myelofibrosis with myeloid metaplasia) | 1295 |
| Ch. 90 | Classification of malignant lymphoid disorders | 1315 |
| Ch. 91 | Acute lymphoblastic leukemia | 1321 |
| Ch. 92 | Chronic lymphocytic leukemia and related diseases | 1343 |
| Ch. 93 | Hairy cell leukemia | 1385 |
| Ch. 94 | Large granular lymphocytic leukemia | 1395 |
| Ch. 95 | Pathology of lymphomas | 1399 |
| Ch. 96 | The non-Hodgkin lymphomas | 1407 |
| Ch. 97 | Hodgkin lymphoma | 1461 |
| Ch. 98 | Plasma cell neoplasms : general considerations | 1483 |
| Ch. 99 | Essential monoclonal gammopathies | 1491 |
| Ch. 100 | Plasma cell myeloma | 1501 |
| Ch. 101 | The amyloidoses | 1535 |
| Ch. 102 | Macroglobulinemia | 1549 |
| Ch. 103 | Heavy chain diseases | 1561 |
| Ch. 104 | Megakaryopoiesis and thrombopoiesis | 1571 |
| Ch. 105 | Platelet morphology, biochemistry, and function | 1587 |
| Ch. 106 | Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis | 1665 |
| Ch. 107 | Control of coagulation reactions | 1695 |
| Ch. 108 | Vascular function in hemostasis | 1715 |
| Ch. 109 | Classification, clinical manifestations, and evaluation of disorders of hemostasis | 1741 |
| Ch. 110 | Thrombocytopenia | 1749 |
| Ch. 111 | Essential thrombocythemia and thrombocytosis | 1785 |
| Ch. 112 | Hereditary qualitative platelet disorders | 1795 |
| Ch. 113 | Acquired qualitative platelet disorders | 1833 |
| Ch. 114 | The vascular purpuras | 1857 |
| Ch. 115 | Hemophilia A and hemophilia B | 1867 |
| Ch. 116 | Inherited deficiencies of coagulation factors II, V, VII, X, XI, and XIII and combined deficiencies of factors V and VIII and of the vitamin K-dependent factors | 1887 |
| Ch. 117 | Hereditary fibrinogen abnormalities | 1909 |
| Ch. 118 | Von Willebrand disease | 1929 |
| Ch. 119 | Antibody-mediated coagulation factor deficiencies | 1947 |
| Ch. 120 | Hemostatic dysfunction related to liver diseases and liver transplantation | 1953 |
| Ch. 121 | Disseminated intravascular coagulation | 1959 |
| Ch. 122 | Hereditary thrombophilia | 1981 |
| Ch. 123 | The antiphospholipid syndrome | 2009 |
| Ch. 124 | Antibody-mediated thrombotic disorders : idiopathic thrombotic thrombocytopenic purpura and heparin-induced thrombocytopenia | 2031 |
| Ch. 125 | Venous thrombosis | 2055 |
| Ch. 126 | Atherothrombosis : disease initiation, progression, and treatment | 2067 |
| Ch. 127 | Fibrinolysis and thrombolysis | 2089 |
| Ch. 128 | Erythrocyte antigens and antibodies | 2119 |
| Ch. 129 | Human leukocyte and platelet antigens | 2137 |
| Ch. 130 | Blood procurement and screening | 2151 |
| Ch. 131 | Preservation and clinical use of erythrocytes and whole blood | 2159 |
| Ch. 132 | Preservation and clinical use of platelets | 2175 |