| The first years of the Inquisition | 1 |
| Document 1 | Recollections of the reign of the Catholic kings, written by Bachiller Andres Bernaldez | 1 |
| Document 2 | Establishing the Inquisition in the kingdom of Aragon | 9 |
| The Inquisition's first targets : Judaizing Conversos in Castile, 1484-1513 | 13 |
| Document 3 | Inquisition proceedings against Isabel, wife of Bachiller Lope de la Higuera, 1484 | 13 |
| Document 4 | Inquisition trial of Pedro de Villegas, 1483-1484 | 17 |
| Document 5 | Inquisition trial of Marina Gonzalez, 1494 | 27 |
| Document 6 | Inquisition trial of Maria Gonzalez, wife of Pedro de Villarreal : Ciudad Real, 1511-1513 | 50 |
| Codification | 61 |
| Document 7 | Gaspar Isidro de Arguello : instructions of the holy office of the Inquisition, handled summarily, both old and new part I | 61 |
| The Alumbrados in Castile, 1525-1532 | 80 |
| Document 8 | 1525 Inquisition edict on the Alumbrados | 80 |
| Document 9 | Letter from Friar Francisco Ortiz to Inquisitor-General Alonso Manrique, April 9, 1529, composed inside the Toledo tribunal of the Inquisition | 93 |
| Document 10 | Testimony by Francisca Hernandez, June 2, 1531 | 103 |
| Document 11 | Summary of the prosecutor's accusation against Antonio de Medrano : Toledo tribunal | 108 |
| Document 12 | Excerpts from the trial of Marie de Cazalla, 1532-1534 | 112 |
| Pondering witchcraft | 153 |
| Document 13 | Deliberations on the reality and heresy of witchcraft, 1526 | 153 |
| The Inquisition at mid-century : blasphemers, hypocrites, Protestants | 164 |
| Document 14 | Trial of Catalina Diaz, wife of Juan Becervil, for blasphemy : penanced May 17, 1543 | 164 |
| Document 15 | Trial of Diego de Almodovar, penanced for blasphemy, 1545 | 166 |
| Document 16 | Heresy and false sanctity of Magdalena de la Cruz, 1544-1546 | 168 |
| Document 17 | Letters from the Suprema, Inquisitor-General Fernando de Veldes, and Philip II on Protestants in the 1550s | 176 |
| Document 18 | Documents pertaining to the trial of Archbishop Bartolome Carranza | 194 |
| Document 19 | Prohibited books | 212 |
| Structure, process, routine | 221 |
| Document 20 | Gasper Isidro de Arguello : instructions of the holy office of the Inquisition, handled summarily, both old and new part II : the "new instructions" of 1561 | 221 |
| Document 21 | Excerpts from the visitation records of the prison in the tribunal of Cordoba, 1569 | 232 |
| The Moriscos | 238 |
| Document 22 | Auto de Fe celebrated in Granada, March 18, 1571 | 238 |
| Document 23 | Letter from the Granada tribunal to the Suprema, December 12, 1574 | 247 |
| The Inquisition in the last decades of the sixteenth century | 248 |
| Document 24 | Scandalous propositions : Friar Juan Bautista de Cubas, Monastery of San Lorenzo el Real : penanced, 1581 | 248 |
| Document 25 | Sentence of Catalina Munoz for false sanctity, 1588 | 252 |
| Document 26 | Auto de Fe celebrated in Granada, May 27, 1593 | 257 |