Signal Transduction by Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E. R. Tatham

From the Publisher

Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work.

Signal Transduction is indispensable for modern life sciences.

Michael B. Yaffe

The text is strikingly comprehensive...Written with a single voice, the chapters integrate elegantly with one another, and provide the reader with both broad and comprehensive viewpoints...Remarkably current and up-to-date, the book promises to be a core text for graduate and advanced undergraduate courses in cell signaling and molecular cell biology, and a valuable reference book for all scientists whose work involves mechanisms of cell communication.

Doody Review Services

Reviewer:Alvin Telser, PhD (Northwestern University Feinberg School of Medicine)
Description:This is a basic and comprehensive textbook on the subject of signal transduction.
Purpose:The authors intend the book to be used as a textbook in an advanced undergraduate or graduate course in this subject area. They also state that they hope and expect it will be interesting and useful to scientists at many levels. Signal transduction has become one of the most active and interesting areas of research in modern cell and molecular biology, which makes this book timely and extremely worthwhile. It is very well written and fully meets the author's objectives.
Audience:The major audience for this book are students who will use the book in a formal course on signal transduction, but it has a great deal of important and useful information and is sufficiently well written that many other scientists will find it useful. The authors are very knowledgeable in the subject area.
Features:The book begins with a very interesting historical perspective and proceeds to discuss all the major areas of signal transduction. The authors employ an excellent balance of experimental data and full color schematic diagrams that will greatly assist readers in understanding the material. There are a substantial number of explanatory margin notes that provide definitions, historical background, or points of general interest that add to the interest and understanding of material in the text.
Assessment:This book is an excellent addition to the line of textbooks that are useful for courses in modern cell and molecular biology. The abundantuse of graphics is outstanding. The writing is excellent. This should become the standard textbook in the area of signal transduction.

Booknews

This textbook examines how the presence of hormones and other intracellular messengers can influence what happens on the inside of their target cells. The European authors describe the mechanisms of cyclic nucleotides and calcium, the covalent modification of proteins and inositol-containing lipids, and their roles in the initiation of intracellular signaling cascades. Annotation c. Book News, Inc., Portland, OR

Rating

5 Stars! from Doody

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