| List of contributors | |
| Preface to the third edition | |
| Acknowledgements/Dedication | |
| 1 | History of rheumatic diseases | |
| 2 | Classification of rheumatic diseases | |
| 3 | Epidemiologic concepts and rheumatology | |
| 4 | Principles of outcome assessment | |
| 5 | The worldwide economic and functional impact of rheumatic disease | |
| 6 | The provision of rheumatologic services | |
| 7 | Principles of health economics and application to rheumatic disorders | |
| 8 | The musculoskeletal system | |
| 9 | Joint physiology | |
| 10 | Biomechanics | |
| 11 | Principles and techniques in molecular biology | |
| 12 | The genetic basis of rheumatic disease | |
| 13 | The principles of adaptive immunity | |
| 14 | Tissue destruction and repair | |
| 15 | Neuropeptides, free radicals and nitric oxide | |
| 16 | Inflammation | |
| 17 | The synovium | |
| 18 | History and physical examination | |
| 19 | Pattern recognition in arthritis | |
| 20 | Laboratory tests in rheumatic disorders | |
| 21 | Testing for ANA and ANCA - diagnostic value and pitfalls | |
| 22 | Synovial fluid analysis | |
| 23 | Aspiration and injection of joints and periarticular tissues | |
| 24 | Minimally invasive procedures | |
| 25 | Imaging principles and techniques | |
| 26 | Skin and rheumatic disease | |
| 27 | The eye and rheumatic diseases | |
| 28 | The heart in rheumatic disease | |
| 29 | The lung in rheumatic diseases | |
| 30 | Gastrointestinal tract and rheumatic disease | |
| 31 | The kidney and rheumatic disease | |
| 32 | Principles of management of patients with rheumatic disease | |
| 33 | Health promotion and patient education for people with arthritis | |
| 34 | Principles of pain and pain management | |
| 35 | Non-steroidal anti-inflammatory drugs | |
| 36 | Systemic glucocorticoids in rheumatology | |
| 37 | Intra-articular and intralesional therapy | |
| 38 | Disease-modifying antirheumatic drugs 1: antimalarials, gold and penicillamine | |
| 39 | Disease-modifying antirheumatic drugs 2: sulfasalazine and dapsone | |
| 40 | Disease-modifying antirheumatic drugs 3: methotrexate | |
| 41 | Disease-modifying antirheumatic drugs 4: leflunomide | |
| 42 | Immunosuppressives | |
| 43 | Immunotherapies: T cell, B cell and complement | |
| 44 | Thalidomide | |
| 45 | Cytokine therapies | |
| 46 | Emerging therapeutic targets | |
| 47 | Antibiotics | |
| 48 | Drugs and pregnancy | |
| 49 | Complementary and alternative medicine | |
| 50 | Principles of rehabilitation | |
| 51 | Principles of arthritis surgery | |
| 52 | Anatomy and biomechanics of the spine | |
| 53 | Neck pain | |
| 54 | Low back pain and lumbar spinal stenosis | |
| 55 | The shoulder | |
| 56 | The elbow | |
| 57 | The wrist and hand | |
| 58 | The hip | |
| 59 | The knee | |
| 60 | The ankle and foot | |
| 61 | Temporomandibular pain syndrome | |
| 62 | Fibromyalgia and related syndromes | |
| 63 | Entrapment neuropathies | |
| 64 | Reflex sympathetic dystrophy (complex regional pain syndrome type I) | |
| 65 | Sports medicine: the clinical spectrum of injury | |
| 66 | History | |
| 67 | Classification and epidemiology | |
| 68 | Clinical features of rheumatoid arthritis | |
| 69 | Extra-articular features of rheumatoid arthritis and systemic involvement | |
| 70 | Adult Still's disease | |
| 71 | Imaging of rheumatoid arthritis | |
| 72 | Genetics of the major histocompatibility complex in rheumatoid arthritis | |
| 73 | Animal models of arthritis | |
| 74 | Autoantibodies in rheumatoid arthritis | |
| 75 | Cellular immunity in rheumatoid arthritis | |
| 76 | Angiogenesis in rheumatoid arthritis | |
| 77 | Rheumatoid synovitis and pannus | |
| 78 | Evaluation and management of early inflammatory polyarthritis | |
| 79 | Evaluation and outcome of the patient with established rheumatoid arthritis | |
| 80 | Management of rheumatoid arthritis; synovitis | |
| 81 | Management of extra-articular disease and complications | |
| 82 | Interdisciplinary care in the management of rheumatoid arthritis | |
| 83 | History | |
| 84 | Classification and epidemiology of juvenile inflammatory arthritis | |
| 85 | Clinical features of juvenile rheumatoid arthritis | |
| 86 | Evaluation of musculoskeletal complaints in children | |
| 87 | Legg-Perthes and other hip diseases in children | |
| 88 | Etiology and pathogenesis of juvenile rheumatoid arthritis | |
| 89 | Management of juvenile idiopathic arthritis | |
| 90 | Connective tissue disease in children | |
| 91 | Rehabilitation in juvenile idiopathic arthritis | |
| 92 | Microorganisms and the locomotor system | |
| 93 | Septic arthritis and osteomyelitis | |
| 94 | Gonococcal arthritis | |
| 95 | Mycobacterial, Brucella, fungal and parasitic arthritis | |
| 96 | Lyme disease and syphilitic arthritis | |
| 97 | Viral arthritis | |
| 98 | Rheumatic aspects of human immunodeficiency virus infection and other immunodeficient states | |
| 99 | Acute rheumatic fever | |
| 100 | History | |
| 101 | Classification of spondyloarthropathies | |
| 102 | Epidemiology and ankylosing spondylitis | |
| 103 | Clinical features of ankylosing spondylitis | |
| 104 | Etiology and pathogenesis of ankylosing spondylitis | |
| 105 | Seronegative spondyloarthropathies: imaging | |
| 106 | Ankylosing spondylitis: pathology | |
| 107 | Ankylosing spondylitis: management | |
| 108 | Reactive arthritis: etiology and pathogenesis | |
| 109 | Reactive arthritis: clinical features and treatment | |
| 110 | Psoriatic arthritis: clinical features | |
| 111 | Psoriatic arthritis: etiology and pathogenesis | |
| 112 | Psoriatic arthritis: management | |
| 113 | Enteropathic arthropathies: diagnosis, pathophysiology and treatment | |
| 114 | Enthesopathy | |
| 115 | History | |
| 116 | Epidemiology and classification of systemic lupus erythematosus | |
| 117 | Immunopathology | |
| 118 | Genetics of lupus | |
| 119 | The complement system | |
| 120 | Autoantibodies in SLE | |
| 121 | Cellular immunology | |
| 122 | Clinical features | |
| 123 | Neonatal lupus | |
| 124 | Drug-induced lupus | |
| 125 | Assessing disease activity and outcome in systemic lupus erythematosus | |
| 126 | Treatment of constitutional symptoms, skin, joint, serositis, cardiopulmonary, hematologic and central nervous system manifestations | |
| 127 | Treatment - renal involvement | |
| 128 | Severe lupus | |
| 129 | Pregnancy in SLE | |
| 130 | Sjogren's syndrome | |
| 131 | Antiphospholipid syndrome | |
| 132 | Epidemiology of systemic sclerosis | |
| 133 | Clinical features of systemic sclerosis | |
| 134 | Systemic sclerosis: etiology and pathogenesis | |
| 135 | Management of systemic sclerosis | |
| 136 | Raynaud's phenomenon | |
| 137 | Localized scleroderma and idiopathic and environmentally - induced scleroderma variants | |
| 138 | Etiology and pathogenesis | |
| 139 | Inflammatory muscle disease: clinical features | |
| 140 | Management | |
| 141 | Inflammatory and metabolic myopathies | |
| 142 | Overlap syndromes | |
| 143 | Overview of the inflammatory vascular diseases | |
| 144 | Biology of the vascular endothelium | |
| 145 | Immunopathogenesis of vasculitis | |
| 146 | Polyarteritis nodosa and microscopic polyangiitis | |
| 147 | Polymyalgia rheumatica and giant cell arteritis | |
| 148 | Wegener's granulomatosis and lymphomatoid granulomatosis | |
| 149 | Churg-Strauss syndrome | |
| 150 | Takayasu's arteritis | |
| 151 | Behcet's syndrome | |
| 152 | Kawasaki disease | |
| 153 | Henoch-Schonlein purpura | |
| 154 | Panniculitis | |
| 155 | Cutaneous vasculitis | |
| 156 | Cryoglobulinemia | |
| 157 | Primary angiitis of the central nervous system | |
| 158 | The hereditary periodic fevers | |
| 159 | Sarcoidosis | |
| 160 | Relapsing polychondritis | |
| 161 | Miscellaneous arthropathies | |
| 162 | Hypertrophic osteoarthropathy | |
| 163 | Cogan's syndrome | |
| 164 | Osteoarthritis: epidemiology and classification | |
| 165 | Clinical features | |
| 166 | Pathogenesis of osteoarthritis | |
| 167 | The genetics of osteoarthritis | |
| 168 | Imaging | |
| 169 | Pathology of osteoarthritis | |
| 170 | Clinical assessment in osteoarthritis | |
| 171 | Management of limb joint osteoarthritis | |
| 172 | Diffuse idiopathic skeletal hyperostosis | |
| 173 | Neuropathic arthropathy | |
| 174 | Osteonecrosis | |
| 175 | History, classification and epidemiology of crystal-related arthropathies | |
| 176 | The pathogenesis of gout | |
| 177 | Clinical features of gout | |
| 178 | The management of gout | |
| 179 | Calcium pyrophosphate dihydrate crystal - associated arthropathy | |
| 180 | Basic calcium phosphate crystal deposition disease | |
| 181 | Other crystals | |
| 182 | Acromegaly | |
| 183 | Bone and joint abnormalities in thyroid diseases | |
| 184 | Diabetes mellitus | |
| 185 | Dialysis arthropathy | |
| 186 | Primary hyperlipidemias and xanthomatosis | |
| 187 | Hemophilia | |
| 188 | Joint and bone lesions in hemoglobinopathies | |
| 189 | Hemochromatosis | |
| 190 | Ochronosis | |
| 191 | The amyloidoses | |
| 192 | Bone structure and function | |
| 193 | Investigation of bone: biochemical markers | |
| 194 | Epidemiology and classification | |
| 195 | Investigations of bone: densitometry | |
| 196 | Pathogenesis of osteoporosis | |
| 197 | Osteoporosis: clinical features | |
| 198 | Management of osteoporosis | |
| 199 | Glucocorticoid-induced osteoporosis | |
| 200 | Rickets and osteomalacia | |
| 201 | Hyperparathyroidism | |
| 202 | Renal bone disease | |
| 203 | Paget's disease of bone | |
| 204 | Gaucher's disease | |
| 205 | Mucopolysaccharidoses | |
| 206 | Heritable connective tissue disorders | |
| 207 | Hypermobility syndrome | |
| 208 | Skeletal dysplasias | |
| 209 | Tumors of bone | |
| Index | |