| Physics of positron emission and annihilation | 2 |
| Basic nuclear physics and positron emission | 2 |
| Annihilation | 5 |
| Positron range and noncolinearity | 9 |
| 511 keV photon interactions in matter | 12 |
| Photoelectric interactions | 12 |
| Compton scattering interactions | 13 |
| Interaction cross-sections in various materials | 14 |
| 511 keV photon detectors | 17 |
| Scintillators | 17 |
| Photomultiplier tubes | 19 |
| Solid state photodetectors | 21 |
| Block detector | 22 |
| Continuous gamma camera detector | 25 |
| Other scintillation detectors | 27 |
| Other gamma ray detectors | 29 |
| Data collection and pet system configurations | 32 |
| Coincidence detection | 32 |
| PET camera : general concepts | 33 |
| Types of events | 35 |
| Prompt coincidences | 38 |
| Resolution : coincidence response functions | 38 |
| Sensitivity : detector and geometric efficiencies | 42 |
| Data representation - the sinogram | 44 |
| Two-dimensional data acquisition | 46 |
| Three-dimensional data acquisition | 48 |
| Data acquisition protocols | 50 |
| Data correction | 51 |
| Normalization | 54 |
| Attenuation correction | 56 |
| Scatter correction | 63 |
| Correction for random coincidences | 65 |
| Dead time correction | 67 |
| Image reconstruction | 70 |
| Backprojection | 71 |
| Analytic reconstruction : projection slice theorem and direct Fourier reconstruction | 72 |
| Two-dimensional analytic reconstruction : filtered backprojection | 76 |
| Limitations of filtered backprojection | 80 |
| Three-dimensional analytic reconstruction | 82 |
| Iterative reconstruction methods | 86 |
| Image analysis | 93 |
| Image display | 93 |
| Calibration and region of interest analysis | 93 |
| Image segmentation | 94 |
| Image registration | 95 |
| Partial volume effects | 97 |
| Performance evaluation of PET systems | 101 |
| Reconstructed spatial resolution | 102 |
| Scatter fraction | 102 |
| Sensitivity | 103 |
| Count-rate performance and dead time | 105 |
| Noise equivalent count rate | 106 |
| Image uniformity | 106 |
| PET system design | 107 |
| High-performance dedicated clinical PET scanners | 107 |
| Lower cost clinical PET scanners | 110 |
| Coincidence imaging on gamma cameras | 110 |
| High-performance brain imaging systems | 111 |
| Other human PET scanners | 112 |
| Multimodality PET imaging | 112 |
| Animal scanners | 114 |