Contents
Contributors
Preface
PART 1:
Introduction to Clinical Medicine
1
The Practice of Medicine
The Editors
2
Global Issues in Medicine
Jim Yong Kim / Paul Farmer
3
Decision-Making in Clinical Medicine
Daniel B. Mark
4
Screening and Prevention of Diseases
Gary J. Martin
5
Principles of Clinical Pharmacology
Dan M. Roden
6
Women’s Health
Andrea Dunaif
7
Medical Disorders during Pregnancy
Robert L. Barbieri / John T. Repke
8
Medical Evaluation of the Surgical Patient
Wei C. Lau / Kim A. Eagle
9
Geriatric Medicine
Lisa B. Caruso / Rebecca A. Silliman
10
Complementary and Alternative Medicine
Stephen E. Straus
11
Palliative and End-of-Life Care
Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel
e1
The Safety and Quality of Health Care
David W. Bates
e2
Economic Considerations in the Practice of Medicine
David Meltzer
e3
Racial and Ethnic Disparities in Health Care
Joseph R. Betancourt / David Blumenthal
e4
Ethical Issues in Clinical Medicine
Bernard Lo
PART 2:
Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
12
Pain: Pathophysiology and Management
Howard L. Fields / Joseph B. Martin
13
Chest Discomfort
Thomas H. Lee
14
Abdominal Pain
William Silen
15
Headache
Peter J. Goadsby / Neil H. Raskin
16
Back and Neck Pain
John W. Engstrom
Section 2:
Alterations in Body Temperature
17
Fever and Hyperthermia
Charles A. Dinarello / Reuven Porat
18
Feverand Rash
Elaine T. Kaye / Kenneth M. Kaye
e5
Atlas of Rashes Associated with Fever
Kenneth M. Kaye / Elaine T. Kaye
19
Fever of Unknown Origin
Jeffery A. Gelfand / Michael V. Callahan
20
Hypothermia and Frostbite
Daniel F. Danzl
Section 3:
Nervous System Dysfunction
21
Syncope
Mark D. Carlson
22
Dizziness and Vertigo
Robert B. Daroff
23
Weakness and Paralysis
Michael J. Aminoff
24
Gait and Balance Disorders
Lewis Sudarsky
25
Numbness, Tingling, and Sensory Loss
Michael J. Aminoff / Arthur K. Asbury
26
Confusion and Delirium
S. Andrew Josephson / Bruce L. Miller
e6
Memory Loss
Thomas D. Bird / Bruce L. Miller
27
Aphasia, Memory Loss, and Other Focal Cerebral Disorders
M.-Marsel Mesulam
28
Sleep Disorders
Charles A. Czeisler / John W. Winkelman / Gary S. Richardson
Section 4:
Disorders of Eyes, Ears, Nose, and Throat
29
Disorders of the Eye
Jonathan C. Horton
30
Disorders of Smell, Taste, and Hearing
Anil K. Lalwani
31
Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections
Michael A. Rubin / Ralph Gonzales / Merle A. Sande
32
Oral Manifestations of Disease
Samuel C. Durso
e7
Atlas of Oral Manifestations of Disease
Samuel C. Durso / Janet A. Yellowitz / Jane C. Atkinson
Section 5:
Alterations in Circulatory and Respiratory Functions
33
Dyspnea and Pulmonary Edema
Richard M. Schwartzstein
34
Cough and Hemoptysis
Steven E. Weinberger / David A. Lipson
35
Hypoxia and Cyanosis
Eugene Braunwald
36
Edema
Eugene Braunwald / Joseph Loscalzo
e8
Approach to the Patient with a Heart Murmur
Patrick T. O’Gara / Eugene Braunwald
37
Palpitations
Joseph Loscalzo
Section 6:
Alterations in Gastrointestinal Function
38
Dysphagia
Raj K. Goyal
39
Nausea, Vomiting, and Indigestion
William L. Hasler
40
Diarrhea and Constipation
Michael Camilleri / Joseph A. Murray
41
Weight Loss
Carol M. Reife
42
Gastrointestinal Bleeding
Loren Laine
43
Jaundice
Daniel S. Pratt / Marshall M. Kaplan
44
Abdominal Swelling and Ascites
Robert M. Glickman / Roshini Rajapaksa
Section 7:
Alterations in Renal and Urinary Tract Function
45
Azotemia and Urinary Abnormalities
Bradley M. Denker / Barry M. Brenner
e9
Atlas of Urinary Sediments and Renal Biopsies
Agnes B. Fogo / Eric G. Neilsen
46
Fluid and Electrolyte Disturbances
Gary G. Singer / Barry M. Brenner
47
Hypercalcemia and Hypocalcemia
Sundeep Khosla
48
Acidosis and Alkalosis
Thomas B. DuBose, Jr.
Section 8:
Alterations in Sexual Function and Reproduction
49
Sexual Dysfunction
Kevin T. McVary
50
Hirsutism and Virilization
David A. Ehrmann
51
Menstrual Disorders and Pelvic Pain
Janet E. Hall
Section 9: Alterations in the Skin
52
Approach to the Patient with a Skin Disorder
Thomas J. Lawley / Kim B. Yancey
53
Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Calvin O. McCall / Thomas J. Lawley
54
Skin Manifestations of Internal Disease
Jean L. Bolognia / Irwin M. Braverman
55
Immunologically Mediated Skin Diseases
Kim B. Yancey / Thomas J. Lawley
56
Cutaneous Drug Reactions
Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub
57
Photosensitivity and Other Reactions to Light
David R. Bickers
e10
Atlas of Skin Manifestations of Internal Disease
Thomas J. Lawley / Stephen Templeton
Section 10:
Hematologic Alterations
58
Anemia and Polycythemia
John W. Adamson / Dan L. Longo
59
Bleeding and Thrombosis
Barbara A. Konkle
60
Enlargement of Lymph Nodes and Spleen
Patrick H. Henry / Dan L. Longo
61
Disorders of Granulocytes and Monocytes
Steven M. Holland /John I. Gallin
e11
Atlas of Hematology and Analysis of Peripheral Blood Smears
Dan L. Longo
PART 3: Genetics and Disease
62
Principles of Human Genetics
J. Larry Jameson / Peter Kopp
63
Chromosome Disorders
Terry J. Hassold / Stuart Schwartz
64
The Practice of Genetics in Clinical Medicine
Susan Miesfeldt / J. Larry Jameson
65
Gene Therapy in Clinical Medicine
Katherine A. High
PART 4:
Regenerative Medicine
66
Stem Cell Biology
Minoru S. H. Ko
67
Applications of Stem Cell Biology in Clinical Medicine
Jack A. Kessler
68
Hematopoietic Stem Cells
David T. Scadden / Dan L. Longo
69
Tissue Engineering
Jennifer Anderson /Joseph P. Vacanti
PART 5: Nutrition
70
Nutritional Requirements and Dietary Assessment
Johanna Dwyer
71
Vitamin and Trace Mineral Deficiency and Excess
Robert M. Russell / Paolo M. Suter
72
Malnutrition and Nutritional Assessment
Douglas C. Heimburger
73
Enteral and Parenteral Nutrition Therapy
Bruce R. Bistrian / David F. Driscoll
74
Biology of Obesity
Jeffrey S. Flier / Eleftheria Maratos-Flier
75
Evaluation and Management of Obesity
Robert F. Kushner
76
Eating Disorders
B. Timothy Walsh
PART 6: Oncology and Hematology
Section 1: Neoplastic Disorders
77
Approach to the Patient with Cancer
Dan L. Longo
78
Prevention and Early Detection of Cancer
Otis W. Brawley / Barnett S. Kramer
79
Cancer Genetics
Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein
80
Cancer Cell Biology and Angiogenesis
Robert G. Fenton / Dan L. Longo
81
Principles of Cancer Treatment
Edward A. Sausville / Dan L. Longo
82
Infections in Patients with Cancer
Robert Finberg
83
Cancer of the Skin
Arthur J. Sober / Hensin Tsao / Carl V. Washington
84
Head and Neck Cancer
Everett E. Vokes
85
Neoplasms of the Lung
John D. Minna / Joan H. Schiller
86
Breast Cancer
Marc E. Lippman
87
Gastrointestinal Tract Center
Robert J. Mayer
88
Tumors of the Liver and Biliary Tree
Brian I. Carr
89
Pancreatic Cancer
Yu Jo Chua / David Cunningham
90
Bladder and Renal Cell Carcinomas
Howard I. Scher / Robert J. Motzer
91
Benign and Malignant Diseases of the Prostate
Howard I. Scher
92
Testicular Cancer
Robert J. Motzer / George J. Bosl
93
Gynecologic Malignancies
Robert C. Young
94
Soft Tissue and Bone Sarcomas and Bone Metastases
Shreyaskumar R. Patel / Robert S. Benjamin
95
Carcinoma of Unknown Primary
Gauri R. Varadhachary /James L. Abbruzzese
96
Paraneoplastic Syndromes: Endocrinologic/Hematologic
J. Larry Jameson / Bruce E. Johnson
97
Paraneoplastic Neurologic Syndromes
Josep Dalmau / Myrna R. Rosenfeld
e12
Thymoma
Dan L. Longo
e13
Late Consequences of Cancer and Its Treatment
Michael C. Perry / Dan L. Longo
Section 2: Hematopoietic Disorders
98
Iron Deficiency and Other Hypoproliferative Anemias
John W. Adamson
99
Disorders of Hemoglobin
Edward J. Benz, Jr.
100
Megaloblastic Anemias
A. Victor Hoffbrand
101
Hemolytic Anemias and Anemia Due to Acute Blood Loss
Lucio Luzzatto
102
Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes
Neal S. Young
103
Polycythemia Vera and Other Myeloproliferative Diseases
Jerry L. Spivak
104
Acute and Chronic Myeloid Leukemia
Meir Wetzler /John C. Byrd / Clara D. Bloomfield
105
Malignancies of Lymphoid Cells
Dan L. Longo
106
Plasma Cell Disorders
Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson
107
Transfusion Biology and Therapy
Jeffery S. Dzieczkowski / Kenneth C. Anderson
108
Hematopoietic Cell Transplantation
Frederick R. Applebaum
Section 3: Disorders of Hemostasis
109
Disorders of Platelets and Vessel Wall
Barbara A. Konkle
110
Coagulation Disorders
Valder Arruda / Katherine A. High
111
Venous Thrombosis
F.R. Rosendaal / H.R. Büller
112
Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Jeffery I. Weitz
PART 7: Infectious Diseases
Section 1: Basic Considerations in Infectious Diseases
113
Introduction to Infectious Diseases: Host-Pathogen Interactions
Lawrence C. Madoff / Dennis L. Kasper
114
Molecular Mechanisms of Microbial Pathogenesis
Gerald B. Pier
115
Approach to the Acutely Ill Infected Febrile Patient
Tamar F. Barlam / Dennis L. Kasper
116
Immunization Principles and Vaccine Use
Gerald T. Keusch / Kenneth J. Bart / Mark Miller
117
Health Advice for International Travel
J.S. Keystone / Phyllis E. Kozarsky
e14
Laboratory Diagnosis of Infectious Diseases
Alexander J. McAdam / Andrew B. Onderdonk
Section 2: Clinical Syndromes: Community-Acquired Infections
118
Infective Endocarditis
Adolf W. Karchmer
119
Infections of the Skin, Muscle, and Soft Tissues
Dennis L. Stevens
120
Osteomyelitis
Jeffrey Parsonnet
121
Intraabdominal Infections and Abscesses
Miriam J. Baron / Dennis L. Kasper
122
Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Joan R. Butterton / Stephen B. Calderwood
123
Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis
Dale N. Gerding / Stuart Johnson
124
Sexually Transmitted Infections: Overview and Clinical Approach
King K. Holmes
e15
Infectious Complications of Burns and Bites
Lawrence C. Madoff / Florencia Pereyra
Section 3: Clinical Syndromes: Health Care-Associated Infections
125
Health Care-Associated Infections
Robert A. Weinstein
126
Infections in Transplant Recipients
Robert Finberg /Joyce Fingeroth
Section 4: Approach to Therapy for Bacterial Diseases
127
Treatment and Prophylaxis of Bacterial Infections
Gordon L. Archer / Ronald E. Polk
Section 5: Diseases Caused by Gram-Positive Bacteria
128
Pneumococcal Infections
Daniel M. Musher
129
Staphylococcal Infections
Franklin D. Lowy
130
Streptococcal and Enterococcal Infections
Michael R. Wessels
131
Diphtheria and Other Infections Caused by Corynebacteria and Related Species
William R. Bishai / John R. Murphy
132
Infections Caused by Listeria monocytogenes
Elizabeth L. Hohmann / Daniel A. Portnoy
133
Tetanus
Elias Abrutyn
134
Botulism
Elias Abrutyn
135
Gas Gangrene and Other Clostridial Infections
Dennis L. Kasper /Lawrence C. Madoff
Section 6: Diseases Caused by Gram-Negative Bacteria
136
Meningococcal Infections
Lee M. Wetzler
137
Gonococcal Infections
Sanjay Ram / Peter A. Rice
138
Moraxella Infections
Daniel M. Musher
139
Haemophilus Infections
Timothy F. Murphy
140
Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
Tamar F. Barlam / Dennis L. Kasper
141
Legionella Infection
Miguel Sabria / Victor L. Yu
142
Pertussis and Other Bordetella Infections
Scott A. Halperin
143
Diseases Caused by Gram-Negative Enteric Bacilli
Thomas A. Russo / James R. Johnson
144
Helicobacter pylori Infections
John C. Atherton / Martin J. Blaser
145
Infections Due to Pseudomonas Species and Related Organisms
Reuben Ramphal
146
Salmonellosis
David A. Pegues / Samuel I. Miller
147
Shigellosis
Philippe Sansonetti / Jean Bergounioux
148
Infections Due to Campylobacter and Related Species
Martin J. Blaser
149
Cholera and Other Vibrioses
Matthew K. Waldor / Gerald T. Keusch
150
Brucellosis
Michael J. Corbel / Nicholas J. Beeching
151
Tularemia
Richard F. Jacobs / Gordon E. Schutze
152
Plague and Other Yersinia Infections
David T. Dennis / Grant L. Campbell
153
Bartonella Infections, Including Cat-Scratch Disease
David H. Spach / Emily Darby
154
Donovanosis
Gavin Hart
Section 7: Miscellaneous Bacterial Infections
155
Nocardiosis
Gregory A. Filice
156
Actinomycosis
Thomas A. Russo
157
Infections Due to Mixed Anaerobic Organisms
Dennis L. Kasper / Ronit Cohen-Poradosu
Section 8: Mycobacterial Diseases
158
Tuberculosis
Mario C. Raviglione / Richard J. O’Brien
159
Leprosy (Hansen’s Disease)
Robert H. Gelber
160
Nontuberculous Mycobacteria
C. Fordham von Reyn
161
Antimycobacterial Agents
Richard J. Wallace, Jr. / David E. Griffith
Section 9: Spirochetal Disease
162
Syphilis
Sheila A. Lukehart
163
Endemic Treponematoses
Sheila A. Lukehart
164
Leptospirosis
Peter Speelman / Rudy Harkskeerl
165
Relapsing Fever
David T. Dennis
166
Lyme Borreliosis
Allen C. Steere
Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
167
Rickettsial Diseases
David H. Walker / J. Stephen Dumler / Thomas Marrie
168
Infections Due to Mycoplasmas
William M. McCormack
169
Chlamydial Infections
Walter E. Stamm
Section 11: Viral Diseases: General Considerations
170
Medical Virology
Fred Wang /Elliott Kieff
171
Antiviral Chemotherapy, Excluding Antiretroviral Drugs
Lindsey R. Baden / Raphael Dolin
Section 12: Infections Due to DNA Viruses
172
Herpes Simplex Viruses
Lawrence Corey
73
Varicella-Zoster Virus Infections
Richard J. Whitley
174
Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Jeffry I. Cohen
175
Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Martin S. Hirsch
176
Molluscum Contagiosum, Monkeypox, and Other Poxviruses, Excluding Smallpox Virus
Fred Wang
177
Parvovirus Infections
Kevin E. Brown
178
Human Papillomavirus Infections
Richard C. Reichman
Section 13: Infections Due to DNA and RNA Respiratory Viruses
179
Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)
Raphael Dolin
180
Influenza
Raphael Dolin
Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
181
The Human Retroviruses
Dan L. Longo /Anthony S. Fauci
182
Human Immunodeficiency Virus Disease: AIDS and Related Disorders
Anthony S. Fauci / H. Clifford Lane
Section 15: Infections Due to RNA Viruses
183
Viral Gastroenteritis
Umesh D. Parashar / Roger I. Glass
184
Enteroviruses and Reoviruses
Jeffery I. Cohen
185
Measles (Rubeola)
Anne Gershon
186
Rubella (German Measles)
Anne Gershon
187
Mumps
Anne Gershon
188
Rabies and Other Rhabdovirus Infections
Alan C. Jackson / Eric C. Johannsen
189
Infections Caused by Arthropod- and Rodent-Borne Viruses
Clarence J. Peters
190
Ebola and Marburg Viruses
Clarence J. Peters
Section 16: Fungal and Algal Infections
191
Diagnosis and Treatment of Fungal Infections
John E. Edwards, Jr.
192
Histoplasmosis
Chadi A. Hage / L. Joseph Wheat
193
Coccidioidomycosis
Neil M. Ampel
194
Blastomycosis
Stanley W. Chapman / Donna C. Sullivan
195
Cryptococcosis
Arturo Casadevall
196
Candidiasis
John E. Edwards, Jr.
197
Aspergillosis
David W. Denning
198
Mucormycosis
Alan M. Sugar
199
Miscellaneous Mycoses and Algal Infections
Stanley W. Chapman / Donna C. Sullivan
200
Pneumocystis Infection
A. Geroge Smulian /Peter D. Walzer
Section 17: Protozoal and Helminthic Infections: General Considerations
e16
Laboratory Diagnosis of Parasitic Infections
Sharon L. Reed / Charles E. Davis
201
Agents Used to Treat Parasitic Infections
Thomas A. Moore
e17
Pharmacology of Agents Used to Treat Parasitic Infections
Thomas A. Moore
Section 18: Protozoal Infections
202
Amebiasis and Infection with Free-Living Amebas
Sharon L. Reed
203
Malaria
Nicholas J. White / Joel G. Breman
204
Babesiosis
Jeffry Gelfand / Edouard Vannier
e18
Atlas of Blood Smears of Malaria and Babesiosis
Nicholas J. White / Joel G. Breman
205
Leishmaniasis
Barbara L. Herwaldt
206
Trypanosomiasis
Louis V. Kirchhoff
207
Toxoplasma Infections
Lloyd H. Kasper
208
Protozoal Intestinal Infections and Trichomoniasis
Peter F. Weller
Section 19: Helminthic Infections
209
Trichinella and Other Tissue Nematodes
Peter F. Weller
210
Intestinal Nematodes
Peter F. Weller /Thomas B. Nutman
211
Filarial and Related Infections
Thomas B. Nutman / Peter F. Weller
212
Schistosomiasis and Other Trematode Infections
Adel A.F. Mahmoud
213
Cestodes
A. Clinton White, Jr. / Peter F. Weller
PART 8: Bioterrorism and Clinical Medicine
214
Microbial Bioterrorism
H. Clifford Lane / Anthony S. Fauci
215
Chemical Bioterrorism
Charles G. Hurst / Jonathan Newmark / James A. Romano, Jr.
216
Radiation Bioterrorism
Zelig A. Tochner / Eli Glatstein
PART 9: Disorders of the Cardiovascular System
Section 1: Introduction to Cardiovascular Disorders
217
Basic Biology of the Cardiovascular System
Joseph Loscalzo / Peter Libby / Eugene Braunwald
218
Epidemiology of Cardiovascular Disease
Thomas A. Gaziano / J. Michael Gaziano
219
Approach to the Patient with Possible Cardiovascular Disease
Eugene Braunwald
Section 2: Diagnosis of Cardiovascular Disorders
220
Physical Examination of the Cardiovascular System
Robert A. O’Rourke /Eugene Braunwald
221
Electrocardiography
Ary L. Goldberger
e19
Atlas of Electrocardiography
Ary L. Goldberger
222
Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging
Rick A. Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik
e20
Atlas of Noninvasive Cardiac Imaging
Rick A. Nishimura / Raymond J. Gibbons / James F. Glockner / A. Jamil Tajik
223
Diagnostic Cardiac Catheterization and Angiography
Donald S. Baim
Section 3: Disorders of Rhythm
224
Principles of Electrophysiology
Gordon F. Tomaselli
225
The Bradyarrhythmias
Gordon F. Tomaselli
226
The Tachyarrhythmias
Francis Marchlinksi
e21
Atlas of Cardiac Arrhythmias
Ary L. Goldberger
Section 4: Disorders of the Heart
227
Heart Failure and Cor Pulmonale
Douglas L. Mann
228
Cardiac Transplantation and Prolonged Assisted Circulation
Sharon A. Hunt
229
Congenital Heart Disease in the Adult
John S. Child
230
Valvular Heart Disease
Patrick O’Gara / Eugene Braunwald
231
Cardiomyopathy and Myocarditis
Joshua Wynne / Eugene Braunwald
232
Pericardial Disease
Eugene Braunwald
233
Tumors and Trauma of the Heart
Eric H. Awtry / Wilson S. Colucci
234
Cardiac Manifestations of Systemic Disease
Eric H. Awtry / Wilson S. Colucci
Section 5: Vascular Disease
235
The Pathogenesis, Prevention, and Treatment of Atherosclerosis
Peter Libby
e22
Atlas of Atherosclerosis
Peter Libby
236
The Metabolic Syndrome
Robert H. Eckel
237
Ischemic Heart Disease
Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo
238
Unstable Angina and Non-ST-Elevation Myocardial Infarction
Christopher P. Cannon / Eugene Braunwald
239
ST-Segment Elevation Myocardial Infarction
Elliott M. Antman / Eugene Braunwald
240
Percutaneous Coronary Intervention
Donald S. Baim
e23
Atlas of Percutaneous Revascularization
Donald S. Baim
241
Hypertensive Vascular Disease
Ted A. Kotchen
242
Diseases of the Aorta
Mark A. Creager / Joseph Loscalzo
243
Vascular Diseases of the Extremities
Mark A. Creager / Joseph Loscalzo
244
Pulmonary Hypertension
Stuart Rich
PART 10: Disorders of the Respiratory System
Section 1: Diagnosis of Respiratory Disorders
245
Approach to the Patient with Disease of the Respiratory System
David A. Lipson / Steven E. Weinberger
246
Disturbances of Respiratory Function
Steven E. Weinberger /Ilene M. Rosen
247
Diagnostic Procedures in Respiratory Diseases
Scott Manaker / Steven E. Weinberger
e24
Atlas of Chest Imaging
Patricia A. Kritek / John J. Reilly, Jr.
248
Asthma
Peter J. Barnes
249
Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
Joel N. Kline / Gary W. Hunninghake
250
Environmental Lung Disease
Frank E. Speizer / John R. Balmes
251
Pneumonia
Lionel A. Mandell / Richard Wunderink
252
Bronchiectasis and Lung Abscess
Gregory Tino / Steven E. Weinberger
253
Cystic Fibrosis
Richard C. Boucher
254
Chronic Obstructive Pulmonary Disease
John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro
255
Interstitial Lung Diseases
Talmadge E. King, Jr.
256
Deep Venous Thrombosis and Pulmonary Thromboembolism
Samuel Z. Goldhaber
257
Disorders of the Pleura and Mediastinum
Richard W. Light
258
Disorders of Ventilation
Eliot A. Phillipson
259
Sleep Apnea
Neil J. Douglas
260
Lung Transplantation
Elbert P. Trulock
PART 11: Critical Care Medicine
Section 1: Respiratory Critical Care
261
Principles of Critical Care Medicine
John P. Kress / Jesse B. Hall
262
Acute Respiratory Distress Syndrome
Bruce D. Levy / Steve D. Shapiro
263
Mechanical Ventilatory Support
Edward P. Ingenito
Section 2: Shock and Cardiac Arrest
264
Approach to the Patient with Shock
Ronald V. Maier
265
Severe Sepsis and Septic Shock
Robert S. Munford
266
Cardiogenic Shock and Pulmonary Edema
Judith S. Hochman / David H. Ingbar
267
Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
Robert J. Myerberg / Agustin Castellanos
Section 3: Neurologic Critical Care
268
Coma
Allan H. Ropper
269
Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage
J. Claude Hemphill, III / Wade S. Smith
Section 4: Oncologic Emergencies
270
Oncologic Emergencies
Rasim Gucalp / Janice P. Dutcher
PART 12: Disorders of the Kidney and Urinary Tract
271
Cellular and Molecular Biology of the Kidney
Alfred L. George, Jr. / Eric G. Neilson
272
Adaptation of the Kidney to Renal Injury
Raymond C. Harris / Eric G. Neilson
273
Acute Renal Failure
Kathleen D. Liu / Glenn M. Chertow
274
Chronic Kidney Disease
Joanne M. Bargman / Karl Skorecki
275
Dialysis in the Treatment of Renal Failure
Kathleen D. Liu / Glenn M. Chertow
276
Transplantation in the Treatment of Renal Failure
Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh
277
Glomerular Diseases
Julia B. Lewis / Eric G. Neilson
278
Polycystic Kidney Disease and Other Inherited Tubular Disorders
David J. Salant / Parul S. Patel
279
Tubulointerstitial Diseases of the Kidney
Alan S. L. Yu / Barry M. Brenner
280
Vascular Injury to the Kidney
Kamal F. Badr / Barry M. Brenner
281
Nephrolithiasis
John R. Asplin / Fredric L. Coe / Murray J. Favus
282
Urinary Tract Infections, Pyelonephritis, and Prostatitis
Walter E. Stamm
283
Urinary Tract Obstruction
Julian L. Seifter / Barry M. Brenner
PART 13: Disorders of the Gastrointestinal System
Section 1: Disorders of the Alimentary Tract
284
Approach to the Patient with Gastrointestinal Disease
William L. Hasler / Chung Owyang
285
Gastrointestinal Endoscopy
Louis Michel Wong-Kee-Song / Mark Topazian
e25
Video Atlas of Gastrointestinal Endoscopy
Louis Michel Wong-Kee-Song / Mark Topazian
286
Diseases of the Esophagus
Raj. K. Goyal
287
Peptic Ulcer Disease and Related Disorders
John Del Valle
288
Disorders of Absorption
Henry J. Binder
289
Inflammatory Bowel Disease
Sonia Friedman / Richard S. Blumberg
290
Irritable Bowel Syndrome
Chung Owyang
291
Diverticular Disease and Common Anorectal Disorders
Susan L. Gearhart
292
Mesenteric Vascular Insufficiency
Susan L. Gearhart
293
Acute Intestinal Obstruction
Susan L. Gearhart / William Silen
294
Acute Appendicitis and Peritonitis
Susan L. Gearhart / William Silen
Section 2: Liver and Biliary Tract Disease
295
Approach to the Patient with Liver Disease
Marc Ghany /Jay H. Hoofnagle
296
Evaluation of Liver Function
Daniel S. Pratt / Marshall M. Kaplan
297
The Hyperbilirubinemias
Allan W. Wolkoff
298
Acute Viral Hepatitis
Jules L. Dienstag
299
Toxic and Drug-Induced Hepatitis
Jules L. Dienstag
300
Chronic Hepatitis
Jules L. Dienstag
301
Alcoholic Liver Disease
Mark E. Mailliard / Michael F. Sorrell
302
Cirrhosis and Its Complications
Bruce R. Bacon
e26
Atlas of Liver Biopsies
Jules L. Dienstag / Atul K. Bhan
303
Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
Bruce R. Bacon
304
Liver Transplantation
Jules L. Dienstag /Raymond T. Chung
305
Diseases of the Gallbladder and Bile Ducts
Norton J. Greenberger / Gustav Paumgartner
Section 3: Disorders of the Pancreas
306
Approach to the Patient with Pancreatic Disease
Phillip P. Toskes / Norton J. Greenberger
307
Acute and Chronic Pancreatitis
Norton J. Greenberger / Phillip P. Toskes
PART 14: Disorders of the Immune System, Connective Tissue, and Joints
Section 1: The Immune System in Health and Disease
308
Introduction to the Immune System
Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci
309
The Major Histocompatability Complex
Gerald T. Nepom
310
Primary Immune Deficiency Diseases
Max D. Cooper / Harry W. Schroeder, Jr.
e27
Primary Immunodeficiencies Associated with or Secondary to Other Diseases
Max D. Cooper / Harry W. Schroeder, Jr.
Section 2: Disorders of Immune-Mediated Injury
311
Allergies, Anaphylaxis, and Systemic Mastocytosis
K. Frank Austen
312
Autoimmunity and Autoimmune Diseases
Peter E. Lipsky / Betty Diamond
313
Systemic Lupus Erythematosus
Bevra Hannahs Hahn
314
Rheumatoid Arthritis
Peter E. Lipsky
315
Acute Rheumatoid Fever
Jonathan R. Carapetis
316
Systemic Sclerosis (Scleroderma) and Related Disorders
John Varga
317
Sjögren’s Syndrome
Haralampos M. Moutsopoulos
318
The Spondyloarthritides
Joel D. Taurog
319
The Vasculitis Syndromes
Carol A. Langford / Anthony S. Fauci
e28
Atlas of Clinical Imaging of the Vasculitic Diseases
Carol A. Langford / Anthony S. Fauci
320
Behçet’s Syndrome
Haralampos M. Moutsopoulos
321
Relapsing Polychondritis
Carol A. Langford /Bruce C. Gilliland
322
Sarcoidosis
Robert P. Baughman /Elyse E. Lower
323
Familial Mediterranean Fever
Daniel L. Kastner
324
Amyloidosis
David C. Seldin / Martha Skinner
Section 3: Disorders of the Joints and Adjacent Tissues
325
Approach to Articular and Musculoskeletal Disorders
John J. Cush / Peter E. Lipsky
326
Osteoarthritis
David T. Felson
327
Gout and Other Crystal Arthropathies
H. Ralph Schumacher / Lan X. Chen
328
Infectious Arthritis
Lawrence C. Madoff
329
Fibromyalgia
Carol A. Langford /Bruce C. Gilliland
330
Arthritis Associated with Systemic Disease and Other Arthritides
Carol A. Langford / Bruce C. Gilliland
331
Periarticular Disorders of the Extremities
Carol A. Langford / Bruce C. Gilliland
PART 15: Endocrinology and Metabolism
Section 1: Endocrinology
332
Principles of Endocrinology
J. Larry Jameson
333
Disorders of the Anterior Pituitary and Hypothalamus
Shlomo Melmed / J. Larry Jameson
334
Disorders of the Neurohypophysis
Gary L. Robertson
335
Disorders of the Thyroid Gland
J. Larry Jameson / Anthony P. Weetman
336
Disorders of the Adrenal Cortex
Gordon H. Williams / Robert G. Dluhy
337
Pheochromocytoma
Hartmut P.H. Neumann
33