(Hardcover)
While it has been known for decades that a deficiency of the essential growth hormone in children is treatable, it was not until 1989 that it was demonstrated that adult-onset growth hormone deficiency (AGHD) in cases of hypopituitary was associated with abnormalities that could be reversed by GH replacement. Jorgensen and Christiansen (both with Aarhus U. Hospital, Denmark) introduce 13 chapters by international endocrinologists updating traditional, novel, and controversial clinical aspects of GH. They review AGHD epidemiology; diagnosis; and classic endpoints of GH therapy: body composition, bone biology, and aerobic exercise capacity. A new focus is the impact of traumatic brain injury on pituitary function. Controversies relate to improved quality of life, reduced mortality, and insurance coverage. Annotation © 2006 Book News, Inc., Portland, OR